coming from Vienna:
highway D1 to the railstation Prague ( Hlavni nadrazi ), first exit right
coming from Berlin, Dresden:
head to Pragues city center, the so called Prague Magistrale, short before
reaching Wenzel Sqaure take the last exit right to Zizkov.
coming from Frankfurt:
highway D5 Prague-Pilsen-Nurnberg to city center, follow Magistrale until
you reach the main railwaystation, there take the first exit right to Zizkov.